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Erik Ingelsson: Grant support

Ongoing Research Support

NIH/NIDDK (1R01DK106236-01A1) Ingelsson (PI) 09/01/16-08/31/21 Beyond GWAS of insulin resistance: An integrated approach to translate genetic association to function

We will perform a series of studies in unique samples of up to 13,811 individuals from the general population, genetically modified zebrafish and cell-based model systems. Our work is anticipated to lead to new important insights to the development of insulin resistance, which in turn can lead to better treatment of this and related conditions.

NIH/NHLBI (1R01HL135313-01) Ingelsson (PI) 09/01/16-08/31/19 Causal associations of circulating biomarkers with cardiovascular disease We will assess the causal role of 36 biomarkers on the development of coronary heart disease, stroke, heart failure, atrial fibrillation and type 2 diabetes in 502,650 participants of the UK Biobank using Mendelian randomization. Our work is anticipated to give important insights regarding the etiological understanding of these diseases and accelerate development of new prevention strategies, including druggable targets. This grant is pending, scored on 6th perc in the initial submission. Knut och Alice Wallenberg Foundation (no. 2013.0126) Ingelsson (PI) 01/01/14-12/31/18 Cardiomics: Use of -omics methods for identification of novel drug targets and clinical biomarkers for coronary heart disease The overall aims of this research program are to improve risk prediction and treatment of coronary heart disease through improved understanding of biology underlying disease development and identification of new biomarkers for improved risk stratification and individualized treatment. The work combines epidemiological studies with functional work in zebrafish. Swedish Heart-Lung Foundation (no. 20140422) Ingelsson (PI) 01/01/15-12/31/17 Beyond GWAS of obesity: An integrated approach to translate genetic association to function Beyond GWAS of obesity: from genetic association to function The aims of this proposal are to characterize genetic loci for obesity using a combination of epidemiological studies, in vivo models in zebrafish and in vitro models in adipocytes and hepatocytes. Swedish Research Council (no. 2014-6361) Ingelsson (PI) 01/01/15-12/31/19 Establishing a Swedish node in European Advanced Translational Research InfraStructure in Medicine (EATRIS.se) The aim of this grant is to initiate a Swedish node of the EATRIS infrastructure, a EU research infrastructure for translational biomedical research.